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The Terme of Levico promoted in the last years several studies by important Universities to strengthen, by scientific proofs, the effectiveness of its water in treating some pathologies of respiratory tract and skin, osteoarthrosis and some gynaecological diseases. The results of these studies are published in important international scientific journals as a confirmation of their validity. Despite their widespread use, much uncertainty exists about the indications and therapeutic mechanisms of nasal thermal water inhalations in the treatment of sinonasal chronic disease. A prospective double-blind study has been instituted in Padua University ENT to evaluate the effects of sulphurous-arsenical-ferruginous thermal water inhalations on nasal respiratory flow, mucociliary transport, nasal cytology, and chemo-physics of nasal mucus in a group of consecutive patients with chronic sinonasal disease. Thirty-seven patients with chronic sinonasal disease underwent a 12-day course of sulphurous-arsenical-ferruginous thermal water warm vapour inhalations (38 degrees C) followed by nasal aerosol of the same thermal water (7 microns micelle). This preliminary study showed that a course of sulphurous-arsenical-ferruginous thermal water inhalations determined a significant improvement in nasal flow and reduction of nasal resistance; a statistically significant reduction of mean mucociliary transport time, from pathologic to physiologic values, has also been shown. Statistical analysis of the data confirmed that the presence of nasal bacteria was significantly reduced by thermal water inhalations.

This year the Terme of Levico will open a new division of nasal irrigation therapy. Consequently, the Terme of Levico entrusted a study to Padua University ENT to evaluate the effects of arsenical-ferruginous thermal water nasal irrigation on sinonasal disease.
Although several publications reported the benefits of nasal irrigation in the management of chronic rhinosinusitis and in sinonasal postoperative care, the available data are poorly controlled. The aim of this prospective randomised study was to compare the effects of sulfurous-arsenical-ferruginous thermal water nasal irrigation vs isotonic sodium chloride solution nasal irrigation after functional endoscopic sinus surgery (FESS) for chronic sinonasal disease considering the histomorphological characteristics of mucosal repair after sinus surgery. Considering the important role of eosinophils in allergic response, this study should suggest sulfurous-arsenical-ferruginous solution nasal irrigation, which significantly reduces local eosinophil count, for allergic patients after FESS for chronic rhinosinusitis. The result of this study are published on the American Journal of Otolaryngology.
Moreover, the Terme of Levico entrusted a study to the University of Siena to confirm the effectiveness of spa therapy with arsenical-ferruginous thermal water. The results of this study are published on Rheumatology International

The aim of the study was to assess the efficacy of Spa therapy and short wave therapy in comparison to conventional therapy in patients with osteoarthritis of the knee in a single blind, randomized, controlled trial. Seventy-four outpatients were enrolled; 30 patients were treated with a combination of daily local mud packs and arsenical ferruginous mineral bath water from the thermal resort of Levico Terme for 3 weeks; 24 patients were treated with short wave therapy for the same period and 20 patients continued regular, routine ambulatory care. Patients were assessed at baseline, upon completion of the 3-week treatment period, and 12 weeks later. Spa therapy and short wave therapy both demonstrated effective symptomatic treatment in osteoarthritis of the knee at the end of the treatment, but only the spa therapy was shown to have efficacy persistent over time. This study demonstrated the superiority of arsenical ferruginous spa therapy compared to short wave therapy in the treatment of osteoarthritis of the knee, probably in relationship to the specific effects of the minerals in this water.
Finally the effectiveness of vaginal irrigation in chronic vaginitis with arsenical ferruginous water has been confirmed by Prof. Danesino of the Gynaecological Department of University of Pavia. The results have been published in vol. 53 n. 1 Minerva Ginecologica, 2000.

Pending trials :
  • ENT Department of Padua: effectiveness on sense of smell in smoker patients with chronic rhinitis treated with nasal irrigations.
  • IRCCS Burlo Garofolo of Trieste: the effectiveness of vaginal irrigation in chronic vaginitis and vaginismus.
  • University of Pavia: the effectiveness of arsenical ferruginous baths on psoriasis.